As we anticipated in last week’s Peoplenomics ChartPack, the market is now in position to break higher despite headwinds. Some of these include falling presidential polls, diesel being a question mark, and the whole intergenerational “Is there some point, here?”
Friction, Folly, and Life
In case you didn’t know, Amazon’s Prime Big Deals are on today and tomorrow (technically to 1 AM Oct. 8). And yes, we got our order in overnight, but there’s not much in this stack.
To “armor up” for the occasion here are three portable ideas to keep within easy reach:
- When you spend money, solve a friction problem. Some things in life just slip along on their own (time). Other conditions involve “friction.” Slow, pernicious opposition to your successful ‘best game.’ Spend money to solve your problems. Things that will genuinely make life better, smoother, less time-wasting around the edges and you’ll be ahead of most.
- Folly to avoid is going along with the crowd. Don’t spend your money following fashion, annual models of automobiles (or software, or….) because that’s the shortest path you’ll find to an empty wallet.
- Life is a “cyclical thing.” When born, you’re an “intelligent spirit” captured in an animal body. When old age ends, you “exit the animal.” Therefore, first half of the ride sets up the second half. So… 1) Buy when young to own when old. 2) When old, think about “spending down” before the exit.
As a Test-Fitting Ape myself, I have to confess to picking up a few baubles; the monkey needs to be entertained. Still, other than a 1:64 balun for the wine room HF antenna ($29) and a telescoping pole for the wine deck end, I’ve managed to keep the dopamine in check. Good luck with yours.
Still, the Xiegu G106 small HF QRP (low power) radio is tempting at $189. This is when the self-talk about “friction” kicks in. See, I already have an assortment of low-power ham radio stations. Heathkit HW-9 complete set, uxSDR, Micro BITX 6, and the computer-based Hermes Lite 2.
Personal Friction Analysis says “Ure problem is time, not assets.” Then quietly, a moment later: “Do you need to write ANOTHER check to not solve the real problem?”
Ah…confession helps. Good luck. The monkey wants another radio as 31 stations doesn’t seem to be enough.
News Compressor: ON
You can almost look at futures pricing and see if “the news” is even worth reading. With the Dow futures up 288 when I checked, the answer on news-reading is “skippable bullshit, mostly…”
Still, we spent the AI money, so you don’t have to. Waders on? Roll ’em up, and let’s stomp.
Middle East first: The interesting thing isn’t that the war has gone away. It hasn’t. It’s that oil is increasingly trading barrels instead of bombs. Middle East exports have remained surprisingly resilient, emergency G7 supplies are coming onto the board, and Brent has slipped below $100 despite continuing Gulf security problems.
Brilliant Bingo time for the ration of Treasury recycling this week. Super marvelous for the Bullish case.
Which reinforces yesterday’s point: watch diesel, tanker insurance, freight and refining more closely than crude. The economic damage may be migrating from not enough oil to expensive plumbing for moving it around. No winner, no chicken dinner – but that’s later.
Ukraine isn’t staying politely inside Ukraine. A Russian drone struck a Ukraine-Moldova border crossing, injuring a Moldovan citizen, while European governments increasingly describe Russian cyber, sabotage and influence operations as a coordinated pressure campaign. Not NATO-versus-Russia shooting yet—but the perimeter continues widening.
France remains our European dashboard item. External wars (Ukraine) are preferable to internal ones (diaspora cost with interest). So? School blockades and union unrest are landing on top of fiscal trouble that helped knock the euro to a 17-month low. French yields backed off Tuesday, but that’s price movement—not problem removal. Europe is beginning to look less like several unrelated stories and more like one accumulating stress system.
Run a travel agency? How about a “Visit Europe before the war” package? You could have six months to a year or three…
Disease gets promoted onto the BlinkLab board. Kenya has confirmed an imported Ebola case from Congo; the patient died and authorities identified 28 potential contacts. Separately, New York declared a statewide measles emergency after 108 cases this year. Neither says “pandemic,” but infectious disease has become active enough to warrant a permanent scan lane again. And you thought “Let’s have shots” meant something else. Didn’t you get the memo?
Inside Pages
Best politicians’ money can buy dept: Brazilian stocks surged after the presidential first round; Spain heads toward a November 29 snap election dominated by housing; Latvia appears headed toward another strongly pro-Ukraine government.
Say hi AI dept: Australia is wrestling with mandatory breach reporting, while industrial AI money keeps getting very real: Schneider Electric’s proposed $22.6-billion PTC acquisition is another reminder that AI isn’t merely chatbot subscriptions anymore.
Domestic ugliness includes a 12-year-old girl killed in crossfire at a Baltimore youth football game. Out West, a M3.7 rattled the Lake Tahoe area without major reported damage.
BlinkLab Trends
Yesterday’s signal survived another 24 hours:
War ? shipping/refining costs.
Ukraine ? wider European perimeter.
France ? financial/social stress.
Disease ? geographic mobility.
That’s four different atoms beginning to merge into two or three compounds. But with Dow futures +288?
The market’s morning vote is essentially:
“Yeah, yeah. Wake us when something breaks.”
Fair enough. Coffee’s still cheaper than panic. Did you see the International Trade presser just out?
Fed rate hike odds, meanwhile, are still running under 22 percent as we look to tomorrow afternoon’s Fed minutes.
Around the Ranch: Woo to PN
Sometime after about 50 years of life, the “spiritual” aspects of the ride come into focus. And often, they don’t fit inside the “neat borders” we like to draw around things here in shared/waking.
Two quite remarkable dreams will be covered on the Peoplenomics side tomorrow. But if you’ve read my novel DreamOver, there’s a scene in that book where one of the characters is talking to a shrink. And he goes into the process of what it’s like to “be” looking at the world through another person’s eyes.
I wrote DreamOver in 2014 when this “being in another person’s head” got real for me. In the novel?
“Interesting, Richard…It’s not often that people even in lucid dreams remember food taste and experience, so that may be notable. Even quite exceptional for an Epic Lucid Dream. “
Sperry sat in his chair while Jan DeVoe thumbed through the careful notes she had been making on Sperry’s exceptional dreams.
Finally, looking up, DeVoe took off her glasses and set them down. “I’m going to record this Richard, if that’s OK with you?”
Sperry nodded.
“What I want you to do now is to go back to the major dream before the “Child Dream”. That’s the one that we call the Eastern Europe Waterfront Dream. Did you do that homework project I asked you to do in case the dreams continued?”
Richard nodded his affirmation.
“Think back as much as you can this long after the fact…where did you think the dream took place? Didn’t you say along the Caspian Sea somewhere?”
“Gosh, I’d almost forgotten that, but it was along the same lines – real intensive visuals. Oh, I did remember to draw a sketch of that one…I’m not a very good artist so I did this on my computer so you’d be able to make sense of it…”
He unfolded a rough computer drawing from his pocket…”
I don’t know if I have ever mentioned this before? But that dream was a personal experience. Compelling and hell. And now, more than a dozen years after its occurrence, the recalled details are just as vivid as any other experience in “waking” from the period.
This time it’s not a Russian fisherman picking up marine supplies. It’s an Asian warlord upstairs with an arms dealer downstairs while in another such “jump” this week…
Well, let’s not ruin tomorrow’s report. Just know that the Western “hard boundary” between fully awake and totally deep in a lucid dream is not a line.
It’s a gradient.
Write when we all wake up,
George@Ure.net
re: “King Lear”, Shakespeare, 1605
feat: Act IV, Scene 1
“Tis the time’s plague when madmen lead the blind.” The earliest journalistic western diaspora of the Siberian plague outbreak story appears to have germinated from “People of Baikal” and subsequently was picked up by “The Moscow Times”. The first outlet is Siberian-founded and now managed from outside Russia. The second media platform is headquartered in the Netherlands.
Both outlets departed Russia following the invasion of the Ukraine. For some reason, their early Siberian plague stories allegedly were given extra public traction via Russian state apparatus leaning Telegram channels.
$AMZN Big Deals…. the Fall spending bell. Cyber Mondaypolla next on deck.
The shiny new factories go to China. And what about the Buckeye Trumpers who lost their jobs to China. I bet they turn into socialists and grab a teat. That’s how it works.
From Trump’s first run:
Donald Trump Says China Remix
https://www.youtube.com/watch?v=RbM2F-cfN0A
“France remains our European dashboard item.”
Euro Death Spiral?
Now the questions are:
Who in their right mind would lend money to a country that’s descending simultaneously into civil war and financial chaos?
How can a country that can’t function without access to credit…function when credit evaporates?
How can the euro continue as a viable currency (i.e., a store of value, medium of exchange, unit of account) if the main countries backing it have lost the support of global capital?
The answers: No one; it can’t; and it won’t.
https://rubino.substack.com/p/open-borders-redgreen-alliance-currency
Lol lol….you can see why to….They have to keep borrowing and expanding the monetary base because the modern financial system depends heavily on credit and liquidity….
Fiat currencies have to keep pushing forward because their influence—and ultimately confidence in them—depends on continued demand…..kind of like potato chips….the success of the potato chip manufacturer is the continued consumption of their chips..the velocity of money…. investing in our own laborers needed essentials,our infrastructure…is important to the systems harmony..
But there is another movement happening at the same time………
BRICS……..
They don’t necessarily have to knock the dollar or the euro off the mountain in one blow.
They can simply built another mountain to be king of……
https://youtu.be/8HqyEHqEYho?si=qwLbCeFdWdC2a9pU
They have to keep borrowing and expanding the monetary base because the modern financial system depends heavily on credit and liquidity. Fiat currencies have to keep pushing forward because their influence—and ultimately confidence in them—depends on continued demand.
But there is another movement happening at the same time…
BRICS.
They don’t necessarily have to knock the dollar or the euro off the mountain in one blow.
They can simply built another mountain to be king of……
Think about it … as one Apollo scientist always said when we were star gazing…..the question isn’t just who prints the most money…….
It’s becoming….and has become….
Where is building and housing the worlds industries…
Who produces the things the world needs using cheap labor as the attracting bait—and what is their money ultimately connected to?
they convinced the planet that their cheap labor would bring those seeking fast gains wealth faster…
they used our greatest weakness against us..our business model…they used deregulation to expedite the end results as well..why should the needs of the wage earners and infrastructure not provide us ..MORE…at a faster rate…
Instead why shouldn’t building homes, maintaining roads, producing goods, educating workers, strengthening communities and building energy infrastructure be viewed as investments in the productive strength of the country rather than simply costs?
Because in my mind everything is like a slow dance…….
We’re all on the dance floor
The music is playing. Every dancer moves a little differently, but everyone is responding to the same music…… Eventually, fifty different dancers can begin swaying together in harmony……or not……
We have choices….. what do we choose…..
We can listen to the music and learn the rhythm……Move as one or many variations of the harmonic frequencies…
OR
We can become wallflowers……
OR
we can walk off the dance floor……
But pretending that we’re dancing alone doesn’t work and will never work……
The world is already dancing together. The question is whether we learn to move in harmony with one another—or keep stepping on each other’s feet…..
Ask anyone in my family…I don’t care if you don’t know how to dance…Hell…I only know the grandpa dance… but everyone is going to get out there and dance..
there are no wall flowers in this family..if you need ill go show you how….
at my grand daughters wedding..I looked over..the only ones on the dance floor were members of my family group..but one by one a few of the other side of the wedding crowd realized..
hell I can’t be any worse at dancing than that moron..in the end the majority relaxed started dancing and had a good time…
its the same thing just a different example…..
George,
Was 6 October 2026 the final SPX peak valuation for the 1982 13/33 year :: x/2.5x 1st and 2nd Fractal Cycle?
From the 30 March 2026 low: 25/60/49 of 49-50 days :: x/2.5x/2x-2x’ 3-phase growth fractal self-assembles to the 6 Oct 2026 all-time peak valuation. The 49 day 3rd fractal of this 3-phase fractal growth series starts on 29 July 2026.
An interpolated 29 July 2026 17/33 of 35/34 day :: xy/2-2.5xy/2-2.5xy terminal peak valuation growth and initial crash decay 3-phase fractal series with a peak valuation on day 33 (6 Oct 2026 ) of the 35 day 2nd fractal and an initial crash nadir on 24 Nov 2026, day 34 of the 3rd fractal, is fractally self-similar to the 1929 12/29/27 day :: xy/2-2.5xy/2-2.5xy 3-phase peak valuation and decay fractal series with a peak on day 4, 3 Sept of the 29 day 2nd fractal and a crash nadir on 13 Nov 1929, day 27 of the 3rd fractal.
Like the terminal 29 days 3rd fractal in 1929 ending on 13 Nov 1929 (and near the end of a 1807 36/90 year :: x/2.5x ending in 1932), there should be a very obvious nonlinear lower low gap in the terminal portion of the 34 day 3rd fractal ending on 24 November 2026.
A 30 March 2026 25/60/49/36 day :: x/2.5x’/2-2.5x’/1.5x’ 4-phase fractal series would end on 24 Nov 2026 and fit the description of the 4-phase fractal series described over 20 years ago in the 2005 main web page of ‘The Economic Fractalist’:
“The ideal growth fractal time sequence is X, 2.5X, 2X and 1.5-1.6X. The first two cycles include a saturation transitional point and decay process in the terminal portion of the cycles. A sudden nonlinear drop in the last 0.5x time period of the 2.5X is the hallmark of a second cycle and characterizes this most recognizable cycle. After the nonlinear gap drop, the third cycle begins. This means that the second cycle can last anywhere in length from 2x to 2.5x. The third cycle 2X is primarily a growth cycle with a lower saturation point and decay process followed by a higher saturation point. The last 1.5-1.6X cycle is primarily a decay cycle interrupted with a mid area growth period. Near ideal fractal cycles can be seen in the trading valuations of many commodities and individual stocks. Most of the cycles are caricatures of the ideal and conform to Gompertz mathematical type saturation and decay curves.
G. Lammert
This page was last updated on 15-May-2005 01:21:59 PM .”
This terminal peak valuation growth and initial crash decay model 4-phase fractal model appears to be correct.
Peter Grandich: U.S. Stock Market – Although I am far from bullish, I have consistently maintained that a stock market crash was unlikely. That is no longer my view. The market now resembles earlier crashes and is flashing several strong bearish technical signals.
While the S & P 500 Index has made a new, all-time high, it’s masking a bear market already underway for many of its members:
https://petergrandich.com/grandich-financial-markets-observations/
Clinton and over here? Bush and over there? 9/11 with Clinton as won Arafat. no two nation approach. Bush won as Iraq, Afgan democrasy. Now Trump? 1) Asia… Japan on ropes for bucking China. 2) S America… Venezula and Argentina in US lap for rest continent change..Brazil. 3) Ukraine under Biden and NATO on ropes for Russia..4) British and funds flows to Moscow and Iran under Bush open policy on ropes with Islam 5) Germany on ropes with France and Euro with Dutch. 6) Africa on ropes with wars and no China policy. 7) Commonwealth on ropes with Trump and Charles and funds flows. Winner? No BRICS post 2030 when Russia oil declines and China can’t suspport rest world. Winner: Britian… over there not over here.
Sounds like you have a bad case of male derangement Syndrome. Where one is not enough. As told to me how many can you use at one time? (your point?) It is a truism for most all males. Be it, Hobbies,, fishing, hunting, TOOLS, even if rarely used. My personal thought is our brain needs a constant focus on the shiny new item. Or we just need it because. (insert whatever explanation works to justify). I sometimes wonder if its our innate need to solve any problem with a simple solution. Without upsetting the wife too much. Oh and there is no cure except the next thing. One thing for sure. It can ALWAYS be justified in all cases!
Floating solves all acquiring issues. It’s really simple. Add more and the waterline gets higher. So simple and visible. And every pound added slows the boat and makes you less safe and comfortable inn heavy conditions. It’s a simple reward process for evaluating everything you put aboard..
no such problem on land. Pile it up. Live in it.
Stiks
Dream last night… a few friends and I were constructing a very perfect scale model of the Golden Gate Bridge, big enough to drive over. One car at a time. Then we proceeded to ‘stress test’ it by shooting ball bearings at it, driving over it, shaking the model, whatever we could do. Woke up thinking about that for a long time.
Since using frequency generator set to 528hz dreams have been fantastic. Fun and adventurous.
Stiks
Tell us how you couple that 528 hz to your environment? coil? leads to wrist – talk to us – we want to etry it!!!
George
We use headphones connected to a generator when sitting conscious, can use a special speaker we got to reach a greater environment; like a whole room. Or we put the generator unplugged frrom speaker or phones at the head of our bed and sleep with it. Tried 412hz for breaking up blood plaque last night. The list of conditions/frequencies is extensive. The devices are all not expensive. Very simple.
Some useful freqs are at ranges you can’t hear.
All fun to see if a few weeks of application can be observed to help. The ones for shoulder pain have seemed to do good. At 80, that’s been a problem. Had lots of high speed crashes windsurfing at 40 knots.
Stiks
Stiks
Thanks – I have plenty of waveform gens here – my buddy Michael up in East Bay San Marin or some such sent me a rife frequency manual – I might try to built up a small ultra lowatator cuff pain frequency, please pass that along too. I saved the wine but the shoulder is on active reserves now for 10+ years.
With a frequency generator…do you necessarily have to hear it…like a dog whistle at 23,000 Hz and 54,000 Hz the frequency is in the air…. but inaudible..the same with light..This frequency band corresponds to wavelengths from roughly 380 to 750 nanometers (nm), though some definitions expand it to 400–700 nm or up to 780 nm…..
Jeff, though we be buying needed stuff, the Missus hardly cares.
GU : “… Personal Friction Analysis says “Ure problem is time, not assets.” …”
There isn’t enough time to share the lifetime of growth. Do what fits in time allowed.
E
“Personal Friction Analysis says “Ure problem is time, not assets.” Then quietly, a moment later: “Do you need to write ANOTHER check to not solve the real problem?” ”
Have you ever thought that perhaps the Universe wants you to
have another radio? And why would that be? Well because
someone else on the other side of the planet already has five
radios (just got his fifth one recently) , and so the Universe ,attempting
to keep things in balance , wants you to get a fifth radio too.
I swear I’ve come across this perusing the internet news.
Somebody gets killed in an elevator accident on the west coast,
Then a day or week or month later, someone gets killed in
an elevator accident on the east coast.
I think there’s some sort of pendulum effect going on , as the
Universe tries to maintain some sort of equilibrium.
So I guess the deeper question is do you want the radio
just because you do, Or do you want the radio because
the Universe wants you to want the radio so that the “balance of
events” is maintained”
Tune your news compressor to watch for “Pendulum Events”
I think you’ll get some intersting stuff.
As for me, I think the Universe is the controller, therefore, I have
no problem assuring myself that absolutely all of my purchases
are stategic in nature .
Write when you get number six.
This is a 2-gold stars great observation!
LOL! How high can you go?
I just sold off a collectible SGC-2020 that I was given from an estate. Made $500 on eBay. I don’t NEED any more radios.
My good fellow, I must expose that you have the Icom 7300 Mk 1 – the earlier version WITHOUT HDMI.
To paraphrase the Einseguy: Minimalism should never involve “feature forfeiture!” My God, what if you NEEDED to look at a 65″: bandscope on 75 meters at night= (between hurricanes?)
Maybe 30+ rigs is a road too farm but self-denial should lose to self-indulgences some of the time, right?
If I NEED the big monitor machine I will get it…. and sell off the old one. Zero sum game.
Bug Grocery is pulling $7.99/lb for 80/20 hamburger.
Trump has to get that Brazilian beef in the house. A good $AMZN Cyber Monday Xmas present from the grocery page – 25 pounds of American burger.
Over/Under Trump will have to bail the American Farm in 2027?
In my Ontario grocery, they sell Australian beef, which we do not buy after trying it and not finding it good. Also there is New Zealand ground beef and again after trying it will not buy anymore, taste seems off.
The ungraded beef,, code word for Mexican and again after having tried it will not get it again.
Canada prime or USDA is best, and have to be selective when out at any restaurant as they will use imported beef.
My blood pressure has always been variable, especially at the Doc’s office. But at home & relaxing I averaged around 120/80… which long ago was considered ‘normal’. But the latest CT scan for ‘other stuff’ had a side note revealing some cardiovascular ‘disease’ (artery buildup) that the Doc noted during a routine visit yesterday, and I blew up a 150/100 for him. So he announced he was putting me on Lisinopril, which is an ACE inhibitor that relaxes the blood vessels to lower pressure. Took first dose last night and slept very well. (Still don’t have my CPAP machine, but that’s another long story). Medicine info says it may take days or weeks for full effect, but today I’m glad I wasn’t driving. Somewhere between dizzy & faint, I was moving slow all day. Home BP gave me a 91/65. Good grief… it’s working! Now I just need to adapt and get used to this feeling… cautiously. No sudden movements.
About 40 years back I had a strict witch of a doctor that put me on BP meds for much less than this. Can’t remember the name, but it was a constant headache, and my feet were numb and caused several trips and falls. Got off the stuff when it interacted badly with some other meds she put me on. But I think this will be tolerable. Tomorrow I start a daily walking regimen out on my country roads, also. Yard work & sweats isn’t enough, apparently.
Longevity… must be present to win.
Hank : I’m also on Lisinopril, twice daily, in addition to a single (nightly) Amlodopine. Both do their jobs and either can make you a bit fuzzy, even faint, while depressing BP. I never take the morning dose without eating something first, with a glass of milk. My suggestion is to also go slow in the hour after dosing.
Egor
ps – my BP used to be referred to as high normal, similar to yours. So far I avoided confrontation about BP meds but, even as a HS swimmer going 7-8 miles in two a day practices, my diastolic norm was in 80s.
Yeah, I think they lowered the standards just so they could sell more pills. After a 30 min. walk this morning (after last night’s dose) I was 118/78, which was about relaxed normal for me. So I can push it up with a bit of exercise.
My local hanai brother has a wildly erratic heart if left untreated. Besides amlodipine and one other, he is on Metoprolol three times a day, by the clock. He can tell ‘it’s time’ for the dose by the feel of his heart starting to pound. Scary stuff. Congenital inherited stuff with him, but so far they are keeping him alive longer than some of his relatives. I’m thankful I’m not that bad off.
“Yeah, I think they lowered the standards just so they could sell more pills.”
They have, several times — both BP and blood sugar.
I don’t know how legit the “adjustments” have been. It is in the medical community’s best interest to keep us above room temperature for as long as possible — not necessarily cognizant or ambulatory, but while we’re breathing, THEY are getting bigbucks from Uncle and the insurance vultures. Despite that, the cynic in me questions whether they strive to keep our BP, heart rate, and lipoproteins within narrow params to enhance our longevity or make us compliant zombies…
(“Hank : I’m also on Lisinopril, twice daily, in addition to a single (nightly) Amlodopine. Both do their jobs and either can make you a bit fuzzy, even faint, while depressing BP. I never take the morning dose without eating something first, with a glass of milk. My suggestion is to also go slow in the hour after dosing.
Egor”)
me to..a few weeks ago now..a resident came out..his lips looked like balloons…now it takes a lot to shock me..I haven’t seen it all but I’ve seen my fair share.. it was an allergic reaction but to what.. was afraid they would pop..they looked like huge water balloons.he was very unstable to…..
sent him in…he had developed a allergic reaction to lisinopril…. the doctor said..when he started getting dizzy and falling we should have sent him in..
At various times I’ve taken a pharmaceutical drug and several natural remedies for BP, all of which had after-effects or didn’t do the job. Then my doctor suggested an herbal supplement that some of her patients raved about. It’s the BEST (at least for me and her other patients)! It’s Rauwolfia Extra by Vitanica, a blend of 10 herbs and a few other healthy items.
https://www.amazon.com/dp/B00161ITPA
I began by taking one daily, but discovered I only needed one every 3-5 days. Works quickly and has no side effects.
Look up reserpine.
I sent Walter and Jensen out for a look-see:
Reserpine is an old blood-pressure drug from Indian snakeroot. It still shows up in research, but it is largely gone from U.S. practice because of side effects, especially depression.
What it is. An indole alkaloid isolated in 1952 from the root of Rauvolfia serpentina (Sarpagandha). The plant had been used in India for centuries as a tranquilizer; Gandhi is often cited as having used it that way. Formula C??H??N?O?, about 609 g/mol. First U.S. approval around 1955–1960.
How it works. It binds VMAT1 and VMAT2, the transporters that load norepinephrine, dopamine, serotonin, and histamine into synaptic vesicles. Binding is so tight it behaves as irreversible: stores empty, leftover transmitter is chewed up by monoamine oxidase, and the effect lasts days to weeks until new transporter protein is made. Peripheral norepinephrine depletion drops heart rate and vascular tone. It also crosses the blood–brain barrier, which is where the psychiatric effects come from.
Clinical history. Used for hypertension, usually with a thiazide or a vasodilator (hydralazine). Large trials found the reserpine-plus-thiazide combination cut mortality. A 2016 Cochrane review rated it about as effective as other first-line antihypertensives for lowering pressure. JNC 8 still listed it as an alternative. Typical adjunct doses were kept at or below 0.25 mg twice a day; below about 0.2 mg/day the main complaint was often nasal congestion.
It was also used as an antipsychotic for severe agitation. That use faded once better drugs arrived.
Why it fell out. At higher doses (especially above 0.5 mg/day) it can cause depression, nightmares, and suicidal ideation — reported in roughly 2–28% of patients depending on dose and series. Other problems: sedation, parkinsonism, bradycardia, fainting, gastric ulceration, diarrhea, weight gain, and sexual dysfunction. MedlinePlus states it is no longer available in the United States and that anyone still on it should switch. DrugBank notes the FDA withdrew approval for oral products containing more than 1 mg. The 2025 AHA/ACC hypertension guideline no longer mentions it; the 2017 guideline had kept it only as a tertiary option. Related VMAT2 inhibitors (tetrabenazine, deutetrabenazine, valbenazine) are still used for Huntington’s chorea and tardive dyskinesia, but they are CNS-selective and shorter-acting.
Why a reader might flag it now. It is being looked at for repurposing, not as a comeback antihypertensive:
NIH National Eye Institute work (reported 2025, eLife) found low-dose reserpine improved photoreceptor survival and preserved phototransduction in a rat model of retinitis pigmentosa. The effect did not depend on which gene was mutated. No approved therapy exists for that disease; the hope is that eye-relevant doses would avoid the old systemic side effects. The retinal target is still unknown.
Lab work is testing it as a partner for doxorubicin in breast cancer (P-glycoprotein / efflux and CD44-related stemness) and as a booster of dendritic-cell cross-presentation and CD8 antitumor responses.
In animal research it is a standard tool: the reserpine-induced myalgia model is used for fibromyalgia-like pain because it depletes monoamines.
Bottom line for a reader note: historically real and evidence-backed for blood pressure, especially with a diuretic, but sidelined by depression risk and better-tolerated drugs. Current interest is experimental — retina and cancer — not a reason to hunt old tablets. Not medical advice.
I am going to order a bottle on payday…its way cheaper by a few hundred than what I’m paying now for my lisinopril……
https://trumprx.gov/p/lisinopril
Good Grief LOOB! Have you checked ‘GoodRX’ coupon prices for lisinopril? 5mg 90count is less than $40, with discounts lower than that with their companion membership… $10/month. With my Akamai Advantage plan my lisinopril is free!
Drug Interactions: Do not combine with aliskiren, sacubitril/valsartan, or use NSAIDs (like ibuprofen) without talking to your doctor, due to risks of kidney injury or low blood pressure.
You also might cut back on apricots and bananas, “reduced salt” nuts, and salt substitutes, because it will play hell with your serum potassium levels…
Speaking of the Russian plague. There is a flat Earther on Rumble who a few months back worked out the math and claimed Trump will be shutting down the country January 6, 2027. At post time a shutdown didn’t seem likely. But now Siberia is shutdown so who knows?